期刊
GENES & DEVELOPMENT
卷 33, 期 5-6, 页码 348-364出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.320796.118
关键词
Polycomb repression; RNAi; transposable elements
资金
- National Natural Science Foundation of China [31301930, 31522051]
- National Institutes of Health (NIH) [R01 GM077582]
- National Science Foundation (NSF) [1158346]
- Projects of International Cooperation and Exchanges Ministry of Science and Technology of China [2013DFG32390]
- Natural Science Foundation of Shandong Province [JQ201706]
- NIH [R01 GM087343]
- NSF [MCB 1411565]
- Department of Pathology at the University of Michigan
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1158346] Funding Source: National Science Foundation
RNAi and Polycomb repression play evolutionarily conserved and often coordinated roles in transcriptional silencing. Here, we show that, in the protozoan Tetrahymena thermophila, germline-specific internally eliminated sequences (IESs)-many related to transposable elements (TEs)-become transcriptionally activated in mutants deficient in the RNAi-dependent Polycomb repression pathway. Germline TE mobilization also dramatically increases in these mutants. The transition from noncoding RNA (ncRNA) to mRNA production accompanies transcriptional activation of TE-related sequences and vice versa for transcriptional silencing. The balance between ncRNA and mRNA production is potentially affected by cotranscriptional processing as well as RNAi and Polycomb repression. We posit that interplay between RNAi and Polycomb repression is a widely conserved phenomenon, whose ancestral role is epigenetic silencing of TEs.
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