4.6 Article

TGF-β1 promotes cell migration in hepatocellular carcinoma by suppressing reelin expression

期刊

GENE
卷 688, 期 -, 页码 19-25

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ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2018.11.033

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TGF-beta 1; Hepatocellular carcinoma; Reelin

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Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is a leading cause of worldwide cancer mortality. Intrahepatic dissemination and extrahepatic metastasis are key factors in malignant growth of HCC. Reducing HCC-associated metastasis is critically dependent on uncovering molecular signaling pathways that promote HCC metastasis. In this study, we explored the effect of TGF-beta 1 and RELN on cell migration, and the relationship between TGF-beta 1 and RELN in HCC cells. The data presented that TGF-beta 1 and RELN showed an opposite expression pattern, and either increased expression of TGF-beta 1 or decreased expression of RELN increased HCC cell migration ability. We also found TGF-beta 1 enhanced cell migration ability was through repressing RELN expression, as overexpression of RELN impaired TGF-beta 1 enhanced cell migration. Our work revealed the relationship between TGF-beta 1 and RELN and uncovered the important role of RELN in suppressing cell migration in I-ICC cells.

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