期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 75, 期 3, 页码 290-297出版社
WILEY
DOI: 10.1111/aji.12471
关键词
Fetomaternal tolerance; glycodelin-A; glycosylation; placentation; preeclampsia
资金
- Hong Kong Research Grant Council [HKU774212, 17122415]
- Sigrid Juselius Foundation
- Medical faculty of the University of Helsinki
Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin-A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in placental development and fetomaternal defense. Glycodelin-A interacts by its unique carbohydrate side chains with the cell surface of various cell types in the human fetomaternal interface, particularly the trophoblasts and the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin-A in the endometrium, uterine flushings, and/or maternal serum correlate with unexplained infertility, early pregnancy loss, and recurrent miscarriage. This review integrates recent studies on the role of glycodelin-A in placental development and fetomaternal tolerance in early pregnancy.
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