期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 53, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2019.02.002
关键词
Zebrafish; Genome; Evolution; GnIH; Domestication; Kisspeptin; Synteny; Gene loss
资金
- Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT), Chile [1160076, 1180403]
- Centro Interdisciplinario de Neurociencia de Valparaiso (CINV) Millennium Institute [P09-022-F]
- Millennium Scientific Initiative of the Ministerio de Economia, Fomento y Turismo, Chile
- [R01 OD011116]
- [R01 GM085318]
Gonadotropin releasing hormone (GnRH) is a highly conserved neuroendocrine decapeptide that is essential for the onset of puberty and the maintenance of the reproductive state. First identified in mammals, the GnRH signaling pathway is found in all classes of vertebrates; homologues of GnRH have also been identified in invertebrates. In addition to its role as a hypothalamic releasing hormone, GnRH has multiple functions including modulating neural activity within specific regions of the brain. These various functions are mediated by multiple isoforms, which are expressed at diverse locations within the central nervous system. Here we discuss the GnRH signaling pathways in light of new reports that reveal that some vertebrate genomes lack GnRH1. Not only do other isoforms of GnRH not compensate for this gene loss, but elements upstream of GnRH1, including kisspeptins, appear to also be dispensable. We discuss routes that may compensate for the loss of the GnRH1 pathway.
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