期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 142, 期 -, 页码 38-51出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2019.03.013
关键词
Oxidative stress; Inflammation; Nutritional supplementation; Pregnancy; Unborn child; Newborn
资金
- 'Fundacion Seneca de la Region de Murcia' Grupo de Excelencia [19900/GERM/15]
- Spanish project from the Spanish Ministry of Science, Innovation, and Universities [AGL2017-83386-R]
- Juan de la Cierva de Incorporacion postdoctoral contract from the Ministry of Economy, Industry, and Competitiveness of Spain [ICJI-2015-25373]
The scientific background of perinatal pathology, regarding both mother and offspring, from the lipidomic perspective, has highlighted the possibility of identifying new, promising clinical markers of oxidative stress and inflammation, closely related to the normal development of unborn and newborn children, together with their application. In this regard, in recent years, significant advances have been achieved, assisted by both newly developed analytical tools and basic knowledge on the biological implications of oxylipins. Hence, in the light of this recent progress, this review aims to provide an update on the relevance of human oxylipins during pregnancy and in the unborn and newborn child, covering two fundamental aspects. Firstly, the evidence from human clinical studies and dietary intervention trials will be used to shed light on the extent to which dietary supplementation can modulate the lipidomic markers of oxidative stress and inflammation in the perinatal state, emphasizing the role of the placenta and metabolic disturbances in the mother and fetus. The second part of this article comprises a review of existing data on specific pathophysiological aspects of human reproduction, in relation to lipidomic markers in pregnant women, unborn children, and newborn children. The information reviewed here evidences the current opportunity to correct reproductive disturbances, in the framework of lipidomics, by fine-tuning dietary interventions.
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