期刊
FITOTERAPIA
卷 134, 期 -, 页码 481-484出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.03.018
关键词
Soft coral; Cembranoid; Lemnalia flava
资金
- National Key Research and Development Program of China [2018YFC0310903]
- Drug Innovation Major Project [2018ZX09711-001-001-009]
- National Natural Science Foundation of China (NSFC) [81520108028, 21672230, 81773628]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
Further chemical investigation of the South China Sea soft coral Lemnalia flava resulted in the isolation and characterization of two new cembranoids, namely, xishaflavalins G and H (1 and 2), along with three known related compounds (3-5). The structures of the new compounds were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. The discovery of cembrane-type diterpenes from soft coral of the genus Lemnalia was reported for the first time. In addition, compound 5 exhibited moderate. inhibitory effects on the ConA-induced T lymphocytes and/or lipopolysaccharide (LPS)-induced B lymphocytes proliferation.
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