期刊
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
卷 17, 期 4, 页码 233-242出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14787210.2019.1585242
关键词
Coxsackievirus A10 (CV-A10); enterovirus 71 (EV-A71); epidemiology; hand; foot and mouth disease (HFMD); vaccine
资金
- Major Special Projects Funding Program [2018ZX09737-011]
- Ministry of Science and Technology of the People's Republic of China
Introduction: Hand, foot, and mouth disease (HFMD) is a common viral childhood illness, that has been a severe public health concern worldwide, particularly in the Asia-Pacific region. According to epidemiological data of HFMD during the past decade, the most prevalent causal viruses were enterovirus (EV)-A71, coxsackievirus (CV)-A16, CV-A6, and CV-A10. The public health burden of CV-A10-related diseases has been underestimated as their incidence was lower than that of EV-A71 and CV-A16 in most HFMD outbreaks. However, cases of CV-A10 infection are more severe, and its genome is more variable, which has alerted the research community worldwide. Areas covered: In this paper, studies on the epidemiology, laboratory diagnosis, clinical manifestations, molecular epidemiology, seroepidemiology, animal models of CV-A10, and vaccines and antiviral strategies against this genotype are reviewed. In addition, the genetic evolution of circulating strains was analyzed. Expert opinion: Multivalent vaccines against EV-A71, CV-A16, CV-A6, and CV-A10 should be a next-step HFMD vaccine strategy.
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