4.7 Article

Carotid plaque composition by CT angiography in asymptomatic subjects: a head-to-head comparison to ultrasound

期刊

EUROPEAN RADIOLOGY
卷 29, 期 11, 页码 5920-5931

出版社

SPRINGER
DOI: 10.1007/s00330-019-06086-y

关键词

Carotid arteries; Computed tomography angiography; Ultrasonography; Plaque; Atherosclerotic

资金

  1. Cardiac Research Fund, University Hospital of Southern Denmark, Esbjerg
  2. Institute of Regional Health Research: Centre South West Jutland, University Hospital of Southern Denmark, Esbjerg
  3. Institute of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark
  4. Edith and Vagn Hedegaard Jensen Foundation, Esbjerg
  5. Karola Jorgensens Research Foundation, Esbjerg
  6. A. P. Moller Foundation, Copenhagen

向作者/读者索取更多资源

Objectives To describe carotid plaque composition by computed tomography angiography (CTA) in asymptomatic subjects and to compare this to carotid plaque assessment by ultrasound, coronary plaques by coronary CTA, and inflammatory biomarkers in plasma. Methods Middle-aged asymptomatic men, n = 43, without known cardiovascular disease and diabetes were included. Plaques in coronary and carotid arteries were evaluated using CTA. Total plaque volumes and plaque composition were assessed by a validated plaque analysis software. The 60% centile cut point was used to divide the population into low or high carotid total plaque volumes. The occurrence of carotid plaques and intima-media thickness (IMT) was estimated by ultrasound. Results Carotid plaque by ultrasound was undiagnosed in 13 of 28 participants (46%) compared to CTA. Participants having carotid plaques by ultrasound had significantly higher absolute volumes of all CTA-defined carotid plaque subtypes and a higher fraction of calcified plaque. A high carotid total plaque volume was independently associated with age (adjusted odds ratio (OR) 1.41 [95% confidence interval (CI) 1.14-1.74], p = 0.001), IMT (adjusted OR 2.26 [95% CI 1.10-4.65], p = 0.03), and D-dimer (adjusted OR 8.86 [95% CI 1.26-62.37], p = 0.03). All coronary plaque features were significantly higher in participants with a high carotid total plaque volume. Conclusion The occurrence of carotid plaques in asymptomatic individuals is underestimated by ultrasound compared to plaque assessment by CTA. Carotid plaque composition by CTA is different in individuals with and without carotid plaques by ultrasound.

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