期刊
EUROPEAN JOURNAL OF CANCER
卷 108, 期 -, 页码 120-128出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2018.11.028
关键词
Non-small cell lung cancer; Pembrolizumab; CC-486; Epigenetics; Azacitidine
类别
资金
- Celgene Corporation
- Merck Sharp Dohme, Corp.
Introduction: Preclinical and early clinical studies suggest that combining epigenetic agents with checkpoint inhibitors can potentially improve outcomes in patients with previously treated advanced non-small cell lung cancer (NSCLC). This phase 2 trial examined second-line pembrolizumab thorn CC-486 (oral azacitidine) in patients with advanced NSCLC. Methods: Patients with one prior line of platinum-containing therapy were randomised in a ratio of 1:1 to CC-486 or placebo, on days 1-14, in combination with pembrolizumab on day 1 of a 21-day cycle. The primary end-point was progression-free survival (PFS). Key secondary end-points included overall survival (OS), overall response rate (ORR) and safety. Results: Among 100 patients randomised (pembrolizumab thorn CC-486: 51; pembrolizumab thorn placebo: 49), most were male (57.0%), were white (87.0%) and had Eastern Cooperative Oncology Group performance status 1 (68.0%). No significant difference in PFS was observed between the pembrolizumab thorn CC-486 and pembrolizumab thorn placebo arms (median, 2.9 and 4.0 months, respectively; hazard ratio [HR], 1.374; 90% confidence interval [CI], 0.926-2.038; P = 0.1789). Median OS was 11.9 months versus not estimable (HR, 1.375; 90% CI, 0.830-2.276; P = 0.2968); ORR was 20% versus 14%. Median treatment duration was shorter (15.0 versus 24.1 weeks), and the number of cycles was lower (5.0 versus 7.0) with pembrolizumab thorn CC-486 versus pembrolizumab thorn placebo. No new safety signals for CC-486 or pembrolizumab were detected. Treatment-emergent adverse events were more common in the pembrolizumab thorn CC-486 arm, particularly gastrointestinal, potentially impacting treatment feasibility. Conclusions: No improvement in PFS was observed with pembrolizumab thorn CC-486 versus pembrolizumab thorn placebo. Decreased treatment exposure due to adverse events may have impacted efficacy with pembrolizumab thorn CC-486. (C) 2018 Elsevier Ltd. All rights reserved.
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