期刊
ENVIRONMENTAL POLLUTION
卷 245, 期 -, 页码 590-599出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.11.031
关键词
Insecticides; Pyrethroids; Endocrine-disrupting chemicals; Hypothalamic-pituitary-gonadal axis; Reproductive health
资金
- National Natural Science Foundation of China [21876151]
- Zhejiang Provincial Natural Science Foundation of China [LR15B070001]
- Zhejiang University K. P. Chao's High Technology Development Foundation
Pyrethroids, a class of ubiquitous insecticides, have been recognized as endocrine-disrupting chemicals (EDCs). A lot of studies have implied the endocrine-disrupting effects of pyrethroids on the hypothalamic-pituitary-gonadal (HPG) axis. However, there are few review articles regarding the effects of pyrethroids on the HPG axis of mammal and human, especially new research progress made in this area. The present review sums up the effects of pyrethroids on the HPG axis-related reproductive outcomes, including epidemiological investigations based on human biomonitoring, animal studies and in vitro tests. Mechanisms have described that the endocrine-disrupting effects of pyrethroids on mammal can be mediated via the interaction with steroid receptors, the direct action on ion channels and signaling molecules. Finally, we summarize the current research gaps and suggest future directions in this topic. (C) 2018 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据