期刊
EMBO REPORTS
卷 20, 期 5, 页码 -出版社
WILEY
DOI: 10.15252/embr.201847388
关键词
hypoxia-inducible factors; hypoxia; immunometabolism; macrophages; neutrophils
资金
- Wellcome Trust [209220]
- MRC [MR/N02995X/1] Funding Source: UKRI
Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of transcription factors known as hypoxia-inducible factors (HIFs). The protein members of the HIF signalling pathway are critical regulators of both the innate and adaptive immune responses, and there is an increasing body of evidence to suggest that the elicited changes occur through cellular metabolic reprogramming. Here, we review the literature on innate immunometabolism to dateand discuss the role of hypoxia in innate cell metabolic reprogramming, and how this determines immune responses.
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