期刊
ELECTROPHORESIS
卷 40, 期 16-17, 页码 2129-2134出版社
WILEY
DOI: 10.1002/elps.201900023
关键词
Fluorescent probe; Hemoglobin; SiNPs; Turn off
资金
- National Natural Science Foundation of China [21075007, 81671411] Funding Source: Medline
- SINOPEC Research and Development Program [217015-6] Funding Source: Medline
- National Key Research and Development Program of China [2017YFF0207800] Funding Source: Medline
In this work, a simple, selective, and sensitive probe for hemoglobin based on the quenched fluorescence of silicon nanoparticles (SiNPs) was fabricated. The SiNPs were synthesized by a simple hydrothermal treatment from N-[3-(trimethoxysilyl)propyl]ethylenediamine and sodium citrate. The as-prepared SiNPs exhibited good water-solubility and high fluorescence with the quantum yield of 70%. The fluorescence of the SiNPs could be remarkably quenched by hemoglobin. A wide linear range was obtained from 50 nM to 4000 nM with a LOD of 40 nM. The quenching mechanism was investigated by UV-Vis absorption spectrometry and time-resolved fluorescence spectrometry.
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