期刊
DRUG DELIVERY
卷 26, 期 1, 页码 318-327出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2019.1582729
关键词
Nanocarrier; 5-FU; polyhydroxyalkanoate; HT-29; colorectal cancer; anticancer efficacy
资金
- Romanian National Authority for Scientific Research and Innovation, CNCS - UEFISCDI [PN-II-RU-TE-2014-4-1272, 3/01.10.2015]
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
Aiming to address the issue of poor bioavailability of most anti-tumor medicines against colorectal cancer, we developed a targeted anticancer nanocarrier using biocarriers able to both bind and easily release their load in a controlled manner. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) carriers were obtained via the emulsification-diffusion method, loaded with 5-fluorouracil and then characterized in terms of particle morphology and size (SEM, DLS), drug uptake and release. The cytotoxic potential of the 5-fluorouracil-loaded polymer nanocarriers on human adenocarcinoma cells (HT-29 cell line) was investigated. The in vitro studies clearly demonstrated that while the nanocarriers themselves slightly alter HT-29 cell viability, when loaded with 5-fluorouracil they significantly decrease cell viability, suggesting that the polymer itself exhibits low cytotoxicity and the drug-loaded carrier acts in an efficient manner to kill HT-29 human adenocarcinoma cells.
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