期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 310, 期 11, 页码 H1479-H1485出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00136.2016
关键词
endothelium-dependent vasodilation; endothelial function; microvascular function; cystic fibrosis
资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R21 DK-100783]
- Vertex Pharmaceuticals Investigator-Initiated Studies Program
Cystic fibrosis (CF) is a genetic, multisystemic disorder with broad clinical manifestations apart from the well-characterized pulmonary dysfunction. Recent findings have described impairment in conduit vessel function in patients with CF; however, whether microvascular function is affected in this population has yet to be elucidated. Using laser-Doppler imaging, we evaluated microvascular function through postocclusive reactive hyperemia (PORH), local thermal hyperemia (LTH), and iontophoresis with acetylcholine (ACh). PORH [518 +/- 174% (CF) and 801 +/- 125% (control), P = 0.039], LTH [1,338 +/- 436% (CF) and 1,574 +/- 620% (control), P = 0.045], and iontophoresis with ACh [416 +/- 140% (CF) and 617 +/- 143% (control), P = 0.032] were significantly lower in patients with CF than control subjects. In addition, the ratio of PORH to LTH was significantly (P = 0.043) lower in patients with CF (55.3 +/- 5.1%) than control subjects (68.8 +/- 3.1%). Significant positive correlations between LTH and forced expiratory volume in 1 s (% predicted) (r = 0.441, P = 0.013) and between the PORH-to-LTH ratio and exercise capacity (r = 0.350, P = 0.049) were observed. These data provide evidence of microvascular dysfunction in patients with CF compared with control subjects. In addition, our data demonstrate a complex relationship between microvascular function and classical markers of disease severity (i. e., pulmonary function and exercise capacity) in CF.
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