期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 95, 期 1, 页码 10-14出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2019.03.013
关键词
FilmArray GI Panel; Molecular diagnostics; Reproducibility; Diagnostic stewardship
资金
- National Institutes of Health [NIH T32 AI 052073-11 A1, T32 AI 007502-22]
Though the FilmArray GI Panel has a reported aggregate specificity and reproducibility of >97% and >99%, respectively, the reproducibility is less understood in clinical practice. We measured the reproducibility of positive results for low-prevalence pathogens. Samples with positive results for selected targets were repeated using a different FilmArray module. Overall, 331 of 373 (89%) results were reproducible. Giardia lamblia (57/57, 100%), Cryptosporidium spp. (61/63, 97%), Cyclospora cayetanensis (34/35, 97%), Plesiomonas shigelloides (17/18, 94%), and Rotavirus A (76/77, 99%) were highly reproducible, while Adenovirus F40/41 (38/54, 70%), Vibrio spp. (8/10, 80%), V. cholerae (3/8, 37.5%), and Yersinia enterocolitica (36/50, 72%) were poorly reproducible. Review of 38 patients with nonreproducible results showed that 19 (50%) had evidence of gastroenteritis and only 6 (16%) had possible infection with the organism that showed a nonreproducible result. Higher false-positive rates with certain targets on FAGP emphasize the need for diagnostic stewardship. (C) 2019 Elsevier Inc. All rights reserved.
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