期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 94, 期 3, 页码 304-313出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2019.01.015
关键词
Ceftobiprole; Cephalosporin; Bacteremia; Surveillance; MRSA; BSI
资金
- Basilea Pharmaceutica International Ltd.
- Department of Health and Human Services
- Office of the Assistant Secretary for Preparedness and Response
- Biomedical Advanced Research and Development Authority [HHSO100201600002C]
Ceftobiprole medocaril, the prodrug of ceftobiprole, is an advanced-generation cephalosporin that is approved in many European and non-European countries for the treatment of adults with hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia and is currently being evaluated in a global phase 3 clinical trial of patients with Staphylococcus aureus bacteremia. This study investigated the in vitro activity of ceftobiprole and comparators against a total of 5466 gram-positive and-negative isolates from bloodstream infections (BSIs) that were collected in the United States during 2016 and 2017 as part of the SENTRY Antimicrobial Surveillance Program. Ceftobiprole was highly active (isolates were >99% susceptible) against S. aureus (including methicillin-resistant S. aureus), coagulase-negative staphylococci, Enterococcus faecalis, streptococci, and non-extended-spectrum beta-lactamase (non-ESBL) phenotype Enterobacteriaceae. As expected, lower activities were observed against Enterococcus faecium, ESBL-phenotype Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. These results support further clinical evaluation of ceftobiprole for the treatment of BSIs caused by susceptible organisms. (C) 2019 Elsevier Inc. All rights reserved.
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