期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 92, 期 -, 页码 99-104出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2018.10.003
关键词
Cardiovascular disease; Ocular diseases; Multiple Sclerosis; Cancer; Systemic Lupus Erythematosis; Endogenous retroviruses
资金
- Intramural Research program of the NIH, NIAID
- Norte Portugal Regional Operational Programme (NORTE2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund [NORTE-01-0145-FEDER-000007]
- FCT [IF/00376/2015]
- NIH [R01 CA174844, R01 CA181258, R01 CA204484]
This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some humanized or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other members of the order Lagomorpha are summarized as this knowledge now applies to new therapeutics being developed for several human diseases including Multiple Sclerosis, Type 1 Diabetes and Cancer.
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