期刊
DEVELOPMENT
卷 146, 期 2, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.167643
关键词
Drosophila; Niche; Germline stem cells; Somatic stem cells; Testis; Intestine; Intestinal stem cells; Enterocytes; Wing disc; Cytokines; Proliferation; Survival; Differentiation; Cell competition; Niche competition; Inflammation; Regeneration; Cellular plasticity; Cell reprogramming
资金
- New York State Stem Cell Science [C32584GG, C32577GG]
- National Institute of Child Health and Human Development grant [R03 HD090422]
The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling is best known for its roles in immunity. However, recent work has demonstrated that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates.
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