期刊
DEVELOPMENT
卷 146, 期 3, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.168955
关键词
Planar polarity; Planar cell polarity (PCP); Patterning Gradient; Mathematical modelling; Asymmetry
资金
- Wellcome Trust [100986/Z/13/Z, 210630/Z/18/Z]
- Biotechnology and Biological Sciences Research Council [BB/R016925/1]
- Wellcome Trust [210630/Z/18/Z, 100986/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/R016925/1] Funding Source: UKRI
Planar polarity is a widespread phenomenon found in many tissues, allowing cells to coordinate morphogenetic movements and function. A common feature of animal planar polarity systems is the formation of molecular bridges between cells, which become polarised along atissue axis. We propose that these bridges provide a general mechanism by which cells interpret different forms of tissue gradients to coordinate directional information. We illustrate this using a generalised and consistent modelling framework, providing a conceptual basis for understanding how different mechanisms of gradient function can generate planar polarity. We make testable predictions of how different gradient mechanisms can influence polarity direction.
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