期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 311, 期 3, 页码 G343-G355出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00372.2015
关键词
fibrosis; inflammation; pancreatic disorder
资金
- National Cancer Institute [P50 CA102701, K12 CA90628]
- Department of Defense [W81XWH-15-1-0257]
- CTSA from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health [UL1 TR000135]
Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere.
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