期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 310, 期 11, 页码 G941-G951出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00232.2015
关键词
enteric glial cells; butyrate; maturation; HDAC; MCT
资金
- SanTdige foundation
- Fondation pour la Recherche Medicale
- SFNEP (Societe Francophone de Nutrition Clinique et Metabolisme)
- FARE (Fonds d'Aide a la Recherche en Gastroenterologie)
- SNFGE (Societe Nationale Francaise de Gastroenterologie)
- Region Pays de la Loire
The postnatal period is crucial for the development of gastrointestinal (GI) functions. The enteric nervous system is a key regulator of GI functions, and increasing evidences indicate that 1) postnatal maturation of enteric neurons affect the development of GI functions, and 2) microbiota-derived short-chain fatty acids can be involved in this maturation. Although enteric glial cells (EGC) are central regulators of GI functions, the postnatal evolution of their phenotype remains poorly defined. We thus characterized the postnatal evolution of EGC phenotype in the colon of rat pups and studied the effect of short-chain fatty acids on their maturation. We showed an increased expression of the glial markers GFAP and S100 beta during the first postnatal week. As demonstrated by immunohistochemistry, a structured myenteric glial network was observed at 36 days in the rat colons. Butyrate inhibited EGC proliferation in vivo and in vitro but had no effect on glial marker expression. These results indicate that the EGC myenteric network continues to develop after birth, and luminal factors such as butyrate endogenously produced in the colon may affect this development.
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