期刊
CYTOTHERAPY
卷 21, 期 4, 页码 393-415出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2019.02.002
关键词
cell- and tissue-based therapy; cellular microenvironment; cell plasticity; inflammation; innate immunity; macrophage activation; macrophages; monocytes
类别
资金
- Arthritis Society's PhD Salary Award [TGP-18-0195]
- Mount Sinai Fellowship (Ontario Student Opportunity Trust Funds)
- Arthritis Society's Young Investigator Operating Grant (TAS-YIO) [15-321]
- Ontario Graduate Scholarship
Cell-based therapies are a rapidly developing area of regenerative medicine as dynamic treatments that execute therapeutic functions multimodally. Monocytes and macrophages, as innate immune cells that control inflammation and tissue repair, are increasing popular clinical candidates due to their spectrum of functionality. In this article, we review the role of monocytes and macrophages specifically in inflammatory and degenerative disease pathology and the evidence supporting the use of these cells as an effective therapeutic strategy. We compare current strategies of exogenously polarized monocyte/macrophage therapies regarding dosage, delivery and processing to identify outcomes, advances and challenges to their clinical use. Monocytes/macrophages hold the potential to be a promising therapeutic avenue but understanding and optimization of disease-specific efficacy is needed to accelerate their clinical use.
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