期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 50, 期 -, 页码 52-59出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2019.03.001
关键词
Diabetes mellitus; Diabetic ulcers; Photobiomodulation; Growth factors; PI3K; AKT; TOR; GSK3; Bcl2; Wound healing
资金
- South African Research Chairs Initiative of the Department of Science and Technology
- National Research Foundation of South Africa [98337]
- University of Johannesburg (URC)
- African Laser Centre (ALC)
- National Research Foundation (NRF)
- Council for Scientific and Industrial Research (CSIR)-National Laser Centre (NLC) Laser Rental Pool Programme
Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3 beta activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Lasers or light emitting diodes (LEDs) provide photon energy with therapeutic benefits (Photobiomodulation-PBM), and has been broadly commended to quicken diabetic wound healing. PBM is efficient in the visible red and near-infrared electromagnetic spectrum, and fluencies ranging from 2 to 6 J/cm(2). However, cellular and molecular mechanisms induced by PBM are not fully understood. In this review we discuss PBM and the PI3K/AKT pathway with specific focus on the mTOR and GSK3 beta downstream activity in diabetic wound healing.
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