期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 20, 期 7, 页码 713-726出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203720666190124165243
关键词
IUGR piglet; MeDIP-Seq; small intestine; liver; muscle
资金
- National Natural Science Foundation of China [31630074, 31129006]
- National Basic Research Program of China [2012CB124703]
- Beijing Municipal Natural Science Foundation [S170001]
- National Key Research and Development Program of China [2016YFD0500506, 2018YFD0501002]
- 111 Project [B16044]
- Jinxinnong Animal Science Developmental Foundation
- Hunan Co-Innovation Center of Animal Production Safety, CICAPS
Intrauterine growth restriction (IUGR) remains a major problem in swine production since the associated low birth weight leads to high rates of pre-weaning morbidity and mortality, and permanent retardation of growth and development. The underlying regulatory mechanisms from the aspects of epigenetic modification has received widespread attention. Studies explore the changes in genome wide methylation in small intestine (SI), liver and longissimus dorsi muscle (LDM) between IUGR and normal birth weight (NBW) newborn piglets using a methylated DNA immunoprecipitation-sequencing (MeDIP-Seq) approach. The data demonstrated that methylated peaks were prominently distributed in distal intergenic regions and the quantities of peaks in IUGR piglets were more than that of NBW piglets. IUGR piglets had relatively high methylated level in promoters, introns and coding exons in all the three tissues. Through KEGG pathway analysis of differentially methylated genes found that 33, 54 and 5 differentially methylated genes in small intestine, liver and longissimus dorsi muscle between NBW and IUGR piglets, respectively, which are related to development and differentiation, carbohydrate and energy metabolism, lipid metabolism, protein turnover, immune response, detoxification, oxidative stress and apoptosis pathway. The objective of this review is to assess the impact of differentially methylation status on developmental delay, metabolic disorders and immune deficiency of IUGR piglets.
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