期刊
CURRENT MEDICAL RESEARCH AND OPINION
卷 35, 期 9, 页码 1535-1544出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03007995.2019.1601944
关键词
Proportion of days covered; medication adherence; prescription data; dispensation data; methods; real-world data
资金
- Instituto de Salud Carlos III from the Spanish Ministry of Health [PS09/02500, PI11/00238, PI13/01721]
- Instituto de Salud Carlos III from the European Regional Development Fund [PS09/02500, PI11/00238, PI13/01721]
Objective: We compare estimates of proportion of days covered (PDC) based on dispensation-only data versus linked prescription and dispensation information, and we analyse their differences in a real-world cohort of patients with osteoporosis.Methods: Prospective cohort study. We compared four alternative measures of PDC, using dispensation-only data: a) with a fixed assessment interval; b) censoring the assessment interval at the moment of the last refill; and using linked prescription and dispensation data: c) considering a minimum prescription gap of three months to interpret interruption by the physician; and d) considering any prescription gap.Results: The mean PDC at 12months for new users was 63.1% using dispensation-only data and a fixed interval, 86.0% using dispensation-only data and a last-refill interval, 81% using linked dispensation and prescription data and censoring any period without prescription, and 78.3% when using linked prescription and dispensation data and censoring periods of at least 3months. For experienced users, the figures were 80.0%, 88.9%, 83% and 81%, respectively. Overall, dispensation-based measures presented issues of patient misclassification.Conclusions: Linked prescription and dispensation data allows for more precise PDC estimates than dispensation-only data, as both primary non-adherence and early non-adherence periods, and fully non-adherent patients, are all identified and accounted for.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据