期刊
CURRENT DRUG TARGETS
卷 20, 期 11, 页码 1141-1155出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450120666190308144448
关键词
P-glycoprotein; central nervous system; immune inflammation; glucocorticoid receptor; microglia; chemokine (C-C motif) ligand 2
资金
- China Pharmaceutical University Double First-Class University project [CPU2018GY23]
- National Major Scientific and Technological Special Project for Significant New Drugs Development during the Thirteenth Five-year Plan Period [2016ZX09101031]
- Jiangsu Provincial Graduate Research and Practice Innovation Program
P-glycoprotein (P-gp) is a member of ATP-Binding Cassette (ABC) transporter family. Because of its characteristic luminal surface location, high transport potency and structural specificity, P-gp is regarded as a selective gatekeeper of the Blood Brain Barrier (BBB) to prevent the entry of toxins or unwanted substances into the brain. In recent years, increasing evidence has shown that P-gp is involved in the immune inflammatory response in the Central Nervous System (CNS) disorders by regulating microglia activation, and mediating immune cell migration. Furthermore, Glucocorticoid Receptor (GR) may play a crucial role in P-gp-mediated microglia activation and immune cell migration via GR-mediated mRNA decay. In this article, we will review P-gp structure, distribution, function, regulatory mechanisms, inhibitors and effects of P-gp in the pathogenesis of several CNS diseases and will discuss the role of P-gp in microglia activation, immune cell migration and the relationship with cytokine secretion.
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