期刊
CRITICAL REVIEWS IN MICROBIOLOGY
卷 45, 期 2, 页码 239-251出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1040841X.2019.1575793
关键词
Helicobacter pylori; gastric cancer; microRNA; mechanism
类别
资金
- National Natural Science Foundation of China [81270036, 30901736]
- Plan to Focus on Research and Development from Science and Technology project of Liaoning Province [2017225029]
- Science and Technology Plan Project of Shenyang City [18-014-4-11]
- Fund for Scientific Research of The First Hospital of China Medical University [FHCMU-FSR]
Epidemiological studies have shown that Helicobacter pylori (HP) infection is a risk factor for gastric cancer (GC). HP infection may induce the release of pro-inflammatory mediators, and abnormally increase the level of reactive oxygen species (ROS), nitric oxide (NO), and cytokines in mucosal epithelial cells of the stomach. However, the specific mechanism underlying the pathogenesis of HP-associated GC is still poorly understood. Recent studies have revealed that abnormal microRNA expression may affect the proliferation, differentiation, and apoptosis of mucosal epithelial cells of the stomach to further influence GC occurrence, development, and metastasis. Herein, we summarize the role of abnormal microRNAs in the regulation of HP-associated GC progression. Abnormal microRNA expression in HP-positive GC may be a biomarker for GC diagnosis, occurrence, and development as well as its targeted treatment and prognosis.
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