期刊
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
卷 60, 期 10, 页码 1760-1768出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2019.1598334
关键词
Aryl hydrocarbon receptor (AhR); tryptophan (Trp); intestinal homeostasis; immune barrier; inflammatory bowel disease (IBD)
资金
- National Key R&D Program of China [2018YFD0500601, 2017YFD0500501]
- National Natural Science Foundation of China [31829004, 31722054, 31472101]
- College of Animal Science and Technology Young Talents Program at China Agricultural University [2017DKA001]
- Beijing Nova Programme Interdisciplinary Cooperation Project [xxjc201804]
- 111 Project [B16044]
- Developmental Fund for Animal Science by Shenzhen Jinxinnong Feed Co., Ltd.
The intestinal homeostasis is an orchestrated dynamic equilibrium state composed of the coexistence and interactions among the nutrients, microbial flora, and immune system. The intestinal balance disorder can trigger a series of diseases, such as inflammatory bowel disease (IBD). Many of tryptophan (Trp) metabolites, such as kynurenine and indole, generated under a series of endogenous enzymes or microbial metabolism, have been reported enable to bind and activate the aryl hydrocarbon receptor (AhR), this series of process is termed the Trp-AhR pathway. The activated Trp-AhR pathway can induce the expression of downstream cytokines such as interleukin-22 (IL-22) and interleukin-17 (IL-17), thereby regulating the intestinal homeostasis. This review highlights the advance of Trp-AhR pathway in the regulation of intestinal homeostasis and provides some insights for the clinical strategies that expect to effectively prevent and treat gut diseases via intervening the Trp-AhR pathway.
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