期刊
CNS NEUROSCIENCE & THERAPEUTICS
卷 25, 期 7, 页码 816-824出版社
WILEY
DOI: 10.1111/cns.13116
关键词
aging; mitochondria; mitochondrial biogenesis; mitophagy; neurodegenerative diseases
资金
- Natural Science Foundation of Jiangsu Province [BK20151233]
- National Natural Science Foundation of China [81571252]
- Suzhou Applied Basic Research Program [SYS201509]
Mitochondria not only supply the energy for cell function, but also take part in cell signaling. This review describes the dysfunctions of mitochondria in aging and neurodegenerative diseases, and the signaling pathways leading to mitochondrial biogenesis (including PGC-1 family proteins, SIRT1, AMPK) and mitophagy (parkin-Pink1 pathway). Understanding the regulation of these mitochondrial pathways may be beneficial in finding pharmacological approaches or lifestyle changes (caloric restrict or exercise) to modulate mitochondrial biogenesis and/or to activate mitophagy for the removal of damaged mitochondria, thus reducing the onset and/or severity of neurodegenerative diseases.
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