相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment
Naveen Kumar et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2018)
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
David C. Wedge et al.
NATURE GENETICS (2018)
cAMP: From Long-Range Second Messenger to Nanodomain Signalling
Nshunge Musheshe et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
Metabolic recoding of epigenetics in cancer
Yi-Ping Wang et al.
CANCER COMMUNICATIONS (2018)
The Prognostic PDE4D7 Score in a Diagnostic Biopsy Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes
Dianne van Strijp et al.
PROSTATE CANCER (2018)
Active surveillance review: contemporary selection criteria, follow-up, compliance and outcomes
Maria Komisarenko et al.
TRANSLATIONAL ANDROLOGY AND UROLOGY (2018)
The CAPRA Score at 10 Years: Contemporary Perspectives and Analysis of Supporting Studies
Jonathan S. Brajtbord et al.
EUROPEAN UROLOGY (2017)
Presence of invasive cribriform or intraductal growth at biopsy outperforms percentage grade 4 in predicting outcome of Gleason score 3+4=7 prostate cancer
Charlotte F. Kweldam et al.
MODERN PATHOLOGY (2017)
EPAC1 overexpression is a prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer
Ding-Ping Sun et al.
ONCOLOGY REPORTS (2017)
Navigating the evolving therapeutic landscape in advanced prostate cancer
E. David Crawford et al.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2017)
Epac1, PDE4, and PKC protein expression and their correlation with AKAP95 and Cx43 in esophagus cancer tissues
Zhiyu Guan et al.
THORACIC CANCER (2017)
Uptake of Active Surveillance for Very-Low-Risk Prostate Cancer in Sweden
Stacy Loeb et al.
JAMA ONCOLOGY (2017)
Enzalutamide: targeting the androgen signalling pathway in metastatic castration-resistant prostate cancer
Jack Schalken et al.
BJU INTERNATIONAL (2016)
A Decade of Active Surveillance in the PRIAS Study: An Update and Evaluation of the Criteria Used to Recommend a Switch to Active Treatment
Leonard P. Bokhorst et al.
EUROPEAN UROLOGY (2016)
Expression of protein kinase A regulatory subunits in benign and malignant human thyroid tissues: A systematic review
Alessandro Del Gobbo et al.
EXPERIMENTAL CELL RESEARCH (2016)
Active surveillance for prostate cancer: a narrative review of clinical guidelines
Sophie M. Bruinsma et al.
NATURE REVIEWS UROLOGY (2016)
Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies
Yanguo Feng et al.
PLOS ONE (2016)
Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies
Leander Van Neste et al.
PROSTATE (2016)
Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases
Rene Boettcher et al.
ONCOTARGET (2016)
Disease-specific death and metastasis do not occur in patients with Gleason score ≤6 at radical prostatectomy
Charlotte F. Kweldam et al.
BJU INTERNATIONAL (2015)
Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression
R. Bottcher et al.
BRITISH JOURNAL OF CANCER (2015)
Dimerization of CAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
Graeme B. Bolger et al.
CELLULAR SIGNALLING (2015)
Active surveillance for the management of localized prostate cancer: Guideline recommendations
Chris Morash et al.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL (2015)
Phosphodiesterase sequence variants may predispose to prostate cancer
Rodrigo B. de Alexandre et al.
ENDOCRINE-RELATED CANCER (2015)
Metastatic Prostate Cancer Incidence and Prostate-specific Antigen Testing: New Insights from the European Randomized Study of Screening for Prostate Cancer
Carlotta Buzzoni et al.
EUROPEAN UROLOGY (2015)
Compliance Rates with the Prostate Cancer Research International Active Surveillance (PRIAS) Protocol and Disease Reclassification in Noncompliers
Leonard P. Bokhorst et al.
EUROPEAN UROLOGY (2015)
Magnetic Resonance Imaging-targeted Biopsy May Enhance the Diagnostic Accuracy of Significant Prostate Cancer Detection Compared to Standard Transrectal Ultrasound-guided Biopsy: A Systematic Review and Meta-analysis
Ivo G. Schoots et al.
EUROPEAN UROLOGY (2015)
Trends in Management for Patients With Localized Prostate Cancer, 1990-2013
Matthew R. Cooperberg et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)
The future of EPAC-targeted therapies: agonism versus antagonism
Euan Parnell et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Neuroendocrine differentiation in prostate cancer: a mechanism of radioresistance and treatment failure
Chang-Deng Hu et al.
FRONTIERS IN ONCOLOGY (2015)
Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential
Ginny L. Powers et al.
MOLECULAR CANCER RESEARCH (2015)
Proposed Morphologic Classification of Prostate Cancer With Neuroendocrine Differentiation
Jonathan I. Epstein et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2014)
The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
Moses Xie et al.
BIOCHEMICAL JOURNAL (2014)
The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells
D. J. P. Henderson et al.
BRITISH JOURNAL OF CANCER (2014)
Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis
Tadashi Kaname et al.
CELLULAR SIGNALLING (2014)
Clinical Validation of an Epigenetic Assay to Predict Negative Histopathological Results in Repeat Prostate Biopsies
Alan W. Partin et al.
JOURNAL OF UROLOGY (2014)
Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up
Fritz H. Schroder et al.
LANCET (2014)
AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer
Emmanuel S. Antonarakis et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
The many faces of neuroendocrine differentiation in prostate cancer progression
Stephane Terry et al.
FRONTIERS IN ONCOLOGY (2014)
Creating Order from Chaos: Cellular Regulation by Kinase Anchoring
John D. Scott et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
cAMP/PKA signaling defects in tumors: Genetics and tissue-specific pluripotential cell-derived lesions in human and mouse
Constantine A. Stratakis
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)
DNA methylation: roles in mammalian development
Zachary D. Smith et al.
NATURE REVIEWS GENETICS (2013)
The changing landscape in the treatment of metastatic castration-resistant prostate cancer
Joelle El-Amm et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2013)
Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
Therese Keravis et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer
Yasser Rehman et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2012)
The CAPRA-S Score A Straightforward Tool for Improved Prediction of Outcomes After Radical Prostatectomy
Matthew R. Cooperberg et al.
CANCER (2011)
Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor
Dennis Merkle et al.
CELLULAR SIGNALLING (2011)
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Sharron H. Francis et al.
PHYSIOLOGICAL REVIEWS (2011)
An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression
Jindan Yu et al.
CANCER CELL (2010)
Aberrant Activation of the Androgen Receptor by NF-κB2/p52 in Prostate Cancer Cells
Nagalakshmi Nadiminty et al.
CANCER RESEARCH (2010)
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
Miles D. Houslay
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Activation of Rap1 Promotes Prostate Cancer Metastasis
Candice L. Bailey et al.
CANCER RESEARCH (2009)
Protein kinase A as a biological target in cancer therapy
Silvio Naviglio et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
Neuroendocrine differentiation in the progression of prostate cancer
Akira Komiya et al.
INTERNATIONAL JOURNAL OF UROLOGY (2009)
In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)
Angela McCahill et al.
CELLULAR SIGNALLING (2008)
Protein kinase A RI-α predicts for prostate cancer outcome:: Analysis of radiation therapy oncology group trial 86-10
Li-Yan Khor et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2008)
Ligand-independent activation of androgen receptors by rho GTPase signaling in prostate cancer
Leah S. Lyons et al.
MOLECULAR ENDOCRINOLOGY (2008)
Quality of life and satisfaction with outcome among prostate-cancer survivors
Martin G. Sanda et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells
Yan Xie et al.
MOLECULAR PHARMACOLOGY (2007)
Androgen-independent growth and turnorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells
Paul D. Deeble et al.
CANCER RESEARCH (2007)
Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line:: A new perspective for an old model
Kirsten D. Mertz et al.
NEOPLASIA (2007)
Androgen dependent regulation of protein kinase A subunits in prostate cancer cells
Anne-Katrine Kvissel et al.
CELLULAR SIGNALLING (2007)
Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells
G. Wang et al.
ONCOGENE (2006)
Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
S Ückert et al.
EUROPEAN UROLOGY (2006)
Phosphodiesterase-4 as a therapeutic target
MD Houslay et al.
DRUG DISCOVERY TODAY (2005)
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
SA Tomlins et al.
SCIENCE (2005)
The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus
J Kim et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2005)
Localized effects of cAMP mediated by distinct routes of protein kinase A
K Tasken et al.
PHYSIOLOGICAL REVIEWS (2004)
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
S Gretarsdottir et al.
NATURE GENETICS (2003)
Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7
DG Wang et al.
CELLULAR SIGNALLING (2003)
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
MD Houslay et al.
BIOCHEMICAL JOURNAL (2003)
Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells -: Identification and characterization of a novel PDE4D5 promoter
IR Le Jeune et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate
S Ückert et al.
JOURNAL OF UROLOGY (2001)
Neuroendocrine differentiation of the LNCaP prostate cancer cell line maintains the expression and function of VIP and PACAP receptors
MG Juarranz et al.
CELLULAR SIGNALLING (2001)
Expression and regulation of prostate androgen regulated transcript-1 (PART-1) and identification of differential expression in prostatic cancer
M Sidiropoulos et al.
BRITISH JOURNAL OF CANCER (2001)
UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions
MB Beard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
