期刊
CLINICAL NUTRITION
卷 39, 期 3, 页码 870-875出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2019.03.020
关键词
Body mass index; Obesity; Metabolic phenotype; Hearing loss
资金
- Industrial Health Foundation
- Industrial Disease Clinical Research Grants [140202-01, 150903-01, 170301-01]
- Japan Society for the Promotion of Science KAKENHI [16H05251]
- Grant of National Center for Global Health and Medicine [28-Shi-1206]
- Grants-in-Aid for Scientific Research [16H05251] Funding Source: KAKEN
Background & aims: The existing yet limited prospective studies reported conflicting results about obesity and hearing loss. We investigated the prospective association between obesity and hearing loss in a large-scale Japanese working population, as well as the association between metabolic phenotype and hearing loss. Methods: The study included 48,549 employees aged 20-64 years and free of hearing loss at baseline. Pure-tone audiometric testing was performed annually to identify hearing loss at 1 and 4 kHz. Cox proportional hazards regression was used to investigate the risk of hearing loss associated with body mass index (BMI) and metabolic phenotype (based on a BM1 of >= 25.0/<25.0 kg/m(2) and presence/absence of >= 2 components of metabolic syndrome, except waist circumference). Baseline and updated information were obtained from annual health checkups. Results: With a median follow-up of 7 years, 1595 and 3625 individuals developed unilateral hearing loss at 1 and 4 kHz, respectively. The adjusted hazard ratios (HR) for hearing loss at 1 kHz were 1.21 (1.08, 1.36) and 1.66 (1.33, 2.08) for those with BMI 25.0-29.9 kg/m(2) and BMI >= 30.0 kg/m(2), respectively, compared to individuals with BMI <25.0 kg/m(2). For hearing loss at 4 kHz, the corresponding HRs were 1.14 (1.05, 1.23) and 1.29 (1.09, 1.52). Compared with metabolically healthy non-obese individuals, the adjusted HRs for hearing loss at 1 kHz were 1.19 (1.03, 1.39), 1.27 (1.01, 1.61), and 1.48 (1.25, 1.76) for unhealthy non-obese, healthy obese, and unhealthy obese individuals, respectively. For hearing loss at 4 kHz, the corresponding HRs were 1.13 (1.04, 1.25), 1.21 (1.04, 1.41), and 1.26 (1.12, 1.41). Conclusions: Overweight and obesity are associated with an increased risk of hearing loss, and meta-bolically unhealthy obesity may confer additional risk. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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