期刊
CLINICAL COLORECTAL CANCER
卷 18, 期 2, 页码 E200-E209出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clcc.2019.02.001
关键词
Nanoparticles; Optical imaging; Photosensitive agent; Targeted therapy; Thermal ablation
类别
资金
- National Institute for Health Research (NIHR) infrastructure at Leeds
- University of Leeds 110 Anniversary Research Scholarship
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multi-functionality, with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapy-based nanomedicines in colorectal cancers. This review presents the current scope of preclinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications. (C) 2019 Elsevier Inc. All rights reserved.
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