4.5 Article

Circulating mast cell progenitors correlate with reduced lung function in allergic asthma

期刊

CLINICAL AND EXPERIMENTAL ALLERGY
卷 49, 期 6, 页码 874-882

出版社

WILEY
DOI: 10.1111/cea.13388

关键词

allergic asthma; asthma; lung function; mast cell progenitors; mast cells

资金

  1. Swedish Heart and Lung Foundation
  2. Agnes and Mac Rudberg's Foundation
  3. Malin and Lennart Philipson Foundation
  4. Axel and Signe Lagerman's Foundation
  5. Swedish Asthma and Allergy Association's Research Foundation [F2016-0045]
  6. Mats Kleberg's Foundation
  7. VINNOVA
  8. Apotekare Hedberg's Foundation
  9. Konsul ThC Bergh's Foundation
  10. Hesselman's Foundation
  11. Vetenskapsradet [2014-03293, 2016-00803]
  12. Akademiska Sjukhuset
  13. Bror Hjerpstedt's Foundation
  14. Stiftelsen for Strategisk Forskning [RB13-0196]
  15. Gillberg's Foundation
  16. Hjart-Lungfonden [20150379, 20160618]
  17. Swedish Foundation for Strategic Research
  18. Swedish Research Council [2016-00803, 2014-03293] Funding Source: Swedish Research Council
  19. Swedish Foundation for Strategic Research (SSF) [RB13-0196] Funding Source: Swedish Foundation for Strategic Research (SSF)

向作者/读者索取更多资源

BackgroundStudies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings.ObjectivesTo explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatic patients and controls.MethodsBlood samples were obtained, and spirometry was performed on 38 well-controlled allergic asthmatic patients and 29 controls. The frequency of blood mast cell progenitors, total serum IgE and 180 inflammation- and immune-related plasma proteins were quantified.ResultsAllergic asthmatic patients and controls had a similar mean frequency of blood mast cell progenitors, but the frequency was higher in allergic asthmatic patients with reduced FEV1 and PEF (% of predicted) as well as in women. The level of fibroblast growth factor 21 (FGF-21) correlated positively with the frequency of mast cell progenitors, independent of age and gender, and negatively with lung function. The expression of Fc epsilon RI on mast cell progenitors was higher in allergic asthmatic patients and correlated positively with the level of total IgE in the controls but not in the asthmatic patients.ConclusionElevated levels of circulating mast cell progenitors are related to reduced lung function, female gender and high levels of FGF-21 in young adults with allergic asthma.

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