期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 49, 期 6, 页码 874-882出版社
WILEY
DOI: 10.1111/cea.13388
关键词
allergic asthma; asthma; lung function; mast cell progenitors; mast cells
资金
- Swedish Heart and Lung Foundation
- Agnes and Mac Rudberg's Foundation
- Malin and Lennart Philipson Foundation
- Axel and Signe Lagerman's Foundation
- Swedish Asthma and Allergy Association's Research Foundation [F2016-0045]
- Mats Kleberg's Foundation
- VINNOVA
- Apotekare Hedberg's Foundation
- Konsul ThC Bergh's Foundation
- Hesselman's Foundation
- Vetenskapsradet [2014-03293, 2016-00803]
- Akademiska Sjukhuset
- Bror Hjerpstedt's Foundation
- Stiftelsen for Strategisk Forskning [RB13-0196]
- Gillberg's Foundation
- Hjart-Lungfonden [20150379, 20160618]
- Swedish Foundation for Strategic Research
- Swedish Research Council [2016-00803, 2014-03293] Funding Source: Swedish Research Council
- Swedish Foundation for Strategic Research (SSF) [RB13-0196] Funding Source: Swedish Foundation for Strategic Research (SSF)
BackgroundStudies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings.ObjectivesTo explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatic patients and controls.MethodsBlood samples were obtained, and spirometry was performed on 38 well-controlled allergic asthmatic patients and 29 controls. The frequency of blood mast cell progenitors, total serum IgE and 180 inflammation- and immune-related plasma proteins were quantified.ResultsAllergic asthmatic patients and controls had a similar mean frequency of blood mast cell progenitors, but the frequency was higher in allergic asthmatic patients with reduced FEV1 and PEF (% of predicted) as well as in women. The level of fibroblast growth factor 21 (FGF-21) correlated positively with the frequency of mast cell progenitors, independent of age and gender, and negatively with lung function. The expression of Fc epsilon RI on mast cell progenitors was higher in allergic asthmatic patients and correlated positively with the level of total IgE in the controls but not in the asthmatic patients.ConclusionElevated levels of circulating mast cell progenitors are related to reduced lung function, female gender and high levels of FGF-21 in young adults with allergic asthma.
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