期刊
CLINICA CHIMICA ACTA
卷 490, 期 -, 页码 34-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2018.12.018
关键词
Endothelial to mesenchymal transition; Vascular remodeling; Endothelial cell; Atherosclerosis
资金
- National Natural Science Foundation of China [81670429, 81470435]
- Double First-Class project for innovative Group of Basic Medicine, University of South China
Endothelial cells are the main components of the heart, blood vessels, and lymphatic vessels, which play an important role in regulating the physiological functions of the cardiovascular system. Endothelial dysfunction is involved in a variety of acute and chronic cardiovascular diseases. As a special type of epithelial-mesenchymal transition (EMT), endothelium to mesenchymal transition (EndMT) regulates the transformation of endothelial cells into mesenchymal cells accompanied by changes in the expression of various transcription factors and cytokines, which is closely related to vascular endothelial injury, vascular remodeling, myocardial fibrosis and valvar disease. Endothelial cells undergoing EndMT lose their endothelial characteristics and undergo a transition toward a more mesenchymal-like phenotype. However, the molecular mechanism of EndMT remains unclear. EndMT, as a type of endothelial dysfunction, can cause vascular remodeling which is a major determinant of atherosclerotic luminal area. Therefore, exploring the important signaling pathways in the process of EndMT may provide novel therapeutic strategies for treating atherosclerotic diseases.
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