期刊
CLINICA CHIMICA ACTA
卷 489, 期 -, 页码 10-20出版社
ELSEVIER
DOI: 10.1016/j.cca.2018.11.028
关键词
Gastric carcinoma (GC); Autophagy; Signalling pathway; Prognosis; Autophagy inhibitor; Autophagy inducer
资金
- construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China)
- Center for Gastric Cancer Research of Hunan Province (University of South China)
- Key Laboratory of Tumour Cellular & Molecular Pathology (University of South China)
- College of Hunan Province
- National Natural Science Foundation of China [30600285, 81071966]
- Key Project of Hunan Province Science and Technology Plan [2012SK2012]
- Scientific Research Fund of Hunan Provincial Education Department [12K093]
- Science Research Project of Hunan Provincial Department of Education [16c1398]
- Science Research and Innovation Project of Hunan Provincial Postgraduate
Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a vital intracellular homeostatic process through which defective proteins and organelles are degraded and recycled under starvation, hypoxia or other specific cellular stress conditions. For both normal cells and tumour cells, autophagy not only sustains cell survival but can also promote cell death. Autophagy-related signalling pathways include mTOR-dependent pathways, such as the AMPK/mTOR and PI3K/Akt/mTOR pathways, and non-mTOR dependent pathways, such as the P53 pathway. Additionally, autophagy plays a dual role in gastric carcinoma (GC), including a tumour-suppressor role and a tumour-promoter role. Long-term Heilcobacter pylori infection can impair autophagy, which may eventually promote tumourigenesis of the gastric mucosa. Moreover, Beclin1, LC3 and P62/SQSTM1 are regarded as autophagy-related markers with GC prognostic value. Autophagy inhibitors and autophagy inducers show promise for GC treatment. This review describes research progress regarding autophagy and its significant role in gastric cancer.
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