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Sebastian Schafer et al.
NATURE GENETICS (2017)
Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy
Florian Hinze et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2016)
Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle Force
John Perkin et al.
BIOPHYSICAL JOURNAL (2015)
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Angharad M. Roberts et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Role of Titin Missense Variants in Dilated Cardiomyopathy
Rene L. Begay et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2015)
5′RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy
Danos C. Christodoulou et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Henk L. Granzier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction
Charles S. Chung et al.
CIRCULATION (2013)
Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation
Nazha Hamdani et al.
CIRCULATION RESEARCH (2013)
The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKII delta) phosphorylates cardiac titin's spring elements
Carlos G. Hidalgo et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)
Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy
Felix W. Friedrich et al.
HUMAN MOLECULAR GENETICS (2012)
A Novel Mechanism Involving Four-and-a-half LIM Domain Protein-1 and Extracellular Signal-regulated Kinase-2 Regulates Titin Phosphorylation and Mechanics
Anna Raskin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Truncations of Titin Causing Dilated Cardiomyopathy
Daniel S. Herman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy
Roman Schoenauer et al.
BASIC RESEARCH IN CARDIOLOGY (2011)
Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth
Izhak Kehat et al.
CIRCULATION RESEARCH (2011)
Muscle ring finger 1 mediates cardiac atrophy in vivo
Monte S. Willis et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
Truncation of Titin's Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction
Henk L. Granzier et al.
CIRCULATION RESEARCH (2009)
PKC Phosphorylation of Titin's PEVK Element A Novel and Conserved Pathway for Modulating Myocardial Stiffness
Carlos Hidalgo et al.
CIRCULATION RESEARCH (2009)
Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling
Lydie Laure et al.
FEBS JOURNAL (2009)
Cardiac hypertrophy: Targeting Raf/MEK/ERK1/2-signaling
Kristina Lorenz et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
Johannes Backs et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
Farah Sheikh et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Truncating mutations in C-terminal titin may cause more severe tibial muscular dystrophy (TMD)
Peter Hackman et al.
NEUROMUSCULAR DISORDERS (2008)
Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy
Takuro Arimura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
Michael H. Radke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region
Jun Peng et al.
CIRCULATION (2007)
M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere
Stefanie Weinert et al.
JOURNAL OF CELL BIOLOGY (2006)
Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy
Yuji Matsumoto et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2005)
The kinase domain of titin controls muscle gene expression and protein turnover
S Lange et al.
SCIENCE (2005)
Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes
NH Purcell et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins
CM Warren et al.
ELECTROPHORESIS (2003)
The δC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
T Zhang et al.
CIRCULATION RESEARCH (2003)
Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy
C Geier et al.
CIRCULATION (2003)
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure
M Gotthardt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2
S Lange et al.
JOURNAL OF CELL SCIENCE (2002)
Identification of ubiquitin ligases required for skeletal muscle atrophy
SC Bodine et al.
SCIENCE (2001)
The muscle-specific enolase is an early marker of human myogenesis
F Fougerousse et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2001)
Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain
T Centner et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)