期刊
CHINESE CHEMICAL LETTERS
卷 31, 期 1, 页码 19-27出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.03.052
关键词
timulus-responsive; Hydrogel; RAFT polymerization; Drug controlled release; Rapid response
资金
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX10301402]
- International Cooperation and Exchange of the National Natural Science Foundation of China [51820105004]
- Science and Technology Program of Guangzhou [201707010094]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086, 2016ZT06S029]
- Science and Technology Planning Project of Shenzhen [JCYJ20170307141438157]
Although intelligent hydrogels have shown bright potential application in biomedical fields, they were prepared by conventional methods and still face many serious challenges, such as uncontrollable stimulus-response and low response sensitivity. Recently, RAFT polymerization provides a versatile strategy for the fabrication of intelligent hydrogels with improved stimulus-response properties, owing to the ability to efficiently construct hydrogel precursors with well-defined structure, such as block copolymer, graft copolymer, star copolymer. In this review, we summarized the recent progress on intelligent hydrogels based on RAFT polymerization with emphasis on their fabrication strategies and applications for controlled drug delivery. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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