期刊
CHINESE CHEMICAL LETTERS
卷 30, 期 4, 页码 847-852出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2019.03.025
关键词
Ferroptosis; Fenton reaction; Reactive oxygen species; Lipid peroxidation; Glutathione peroxidase 4
资金
- National Key Research and Development Program of China [2016YFA0203600]
- National Natural Science Foundation of China [31822019, 91859116, 51703195]
- Fundamental Research Funds for the Central Universities [2018QNA7020]
- One Belt and One Road International Cooperation Project from Key Research and Development Program of Zhejiang Province [2019C04024]
Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much attention since it was first identified in 2012. A lot of progress has been made in unraveling its mechanisms and therapeutic potential as a target for cancer therapy. Hitherto, there are mainly two strategies widely adopted for designing ferroptosis-inducing agents, which include increasing the intracellular reactive oxygen species (ROS) level by Fenton reaction, and inactivating the glutathione peroxidase 4 (GPX4). In this mini-review, we summarize the recent advances in ferroptosis-based anticancer treatments with a highlight on nanomaterials, and discuss the current challenges faced by those agents from the perspective of in vivo applications. Moreover, by generalizing ferroptosis induced by excess iron ions to cell death caused by the polyvalent metal-mediated oxidative burden, we introduce a new paradigm of cancer treatment by exploiting various polyvalent metals to disrupt the vulnerable redox balance in cancer cells, which may greatly diversify our arsenal to combat cancer. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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