期刊
CHEMSUSCHEM
卷 12, 期 7, 页码 1349-1360出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201900007
关键词
biocatalysis; life cycle assessment; oxidative chemistry; process metrics; sustainable chemistry
资金
- European Union (EU) project ROBOX under the EUs Horizon 2020 Programme Research and Innovation actions H2020-LEIT BIO-2014-1 [635734]
Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65 +/- 0.59)kgCO2 g(product)(-1) vs. (1.64 +/- 0.67)kgCO2 g(product)(-1)]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.
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