期刊
CHEMOSPHERE
卷 218, 期 -, 页码 197-204出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.11.106
关键词
Sulfadiazine; Ciprofloxacin; Biofilm; Antibiotic resistance genes; Enzymatic activities; Extracellular polymeric substances
资金
- National Natural Science Foundation of China [51878654, 51838005]
- Chinese Academy of Sciences [QYZDY-SSW-DQC004]
- Federal Department of Chinese Water Control and Treatment [2017ZX07108, 2017ZX07501002]
Effects of sulfadiazine and ciprofloxacin on microorganisms in biofilm of drinking water distribution systems (DWDSs) were studied. The results verified that the increases of 16S rRNA for total bacteria and bacterial genus Hyphomicrobium were related to the promotion of antibiotic resistance genes (ARGs) and class 1 integrons (int1) in DWDSs with sulfadiazine and ciprofloxacin. Moreover, the bacteria showed higher enzymatic activities in DWDSs with sulfadiazine and ciprofloxacin, which resulted in more production of extracellular polymeric substances (EPS). The higher contents of EPS proteins and secondary structure beta-sheet promoted bacterial aggregation and adsorption onto surface of pipelines to form biofilm. EPS can serve as a barrier for the microorganisms in biofilm. Therefore, the biofilm bacterial communities shifted and the 16S rRNA for total bacteria increased in DWDSs with antibiotics, which also drove the ARGs promotion. Furthermore, the two antibiotics exhibited stronger combined effects than that caused by sulfadiazine and ciprofloxacin alone. (C) 2018 Published by Elsevier Ltd.
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