期刊
CHEMOSPHERE
卷 216, 期 -, 页码 396-403出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2018.10.101
关键词
Fine particulate matter; Long non-coding RNA; Cis regulation; Trans regulation; Human endothelial cell
资金
- National Natural Science Foundation of China [21876026, 31671034, 81473003, 81673218, 81573186, 81302461, 81502783]
- Provincial Natural Science Founds of Jiangsu [BK20180371]
- Medical Technology Development Program Foundation of Nanjing [ZKX16068]
- Scientific Research Foundation of Graduate School of Southeast University [Y1411848]
Epidemiological studies and experimental research have illustrated that PM2.5 has an association with cardiovascular adverse events. However, the underlying mechanisms are still unknown. Long non-coding RNAs (lncRNAs) have been proposed to take part in diverse diseases. To comprehensively gain insight into the molecular toxicity of PM2.5, expression patterns are analyzed in EA.hy926 cell line through RNAs microarray. A total of 356 lncRNA transcripts are dysregulated in 2.5 mu g/cm(2) group, and there are 1283 lncRNAs differentially expressed in 10 mu g/cm(2) group. From functional analysis, several lncRNAs may be implicated in the bio-pathways of phagosome, TNF signaling pathway, chemokine signaling pathway and gap junction. Moreover, certain lncRNAs participate in the toxicity of PM2.5 through cis-and/or trans regulation of their co-expressed genes. Therefore, lncRNAs may be used as new candidate biomarkers and potentially preventive targets in cardiotoxicity of PM2.5. Our study indicates that not limited to transcriptional regulation, post-transcriptional regulation plays a pivotal role in PM2.5-caused toxicity. (C) 2018 Elsevier Ltd. All rights reserved.
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