4.5 Article

Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M4 Positive Allosteric Modulators

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Michael R. Wood et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Review Clinical Neurology

Best practice in the management of behavioural and psychological symptoms of dementia

Olivier Pierre Tible et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2017)

Article Chemistry, Medicinal

Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping

Madeline F. Long et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Review Biochemistry & Molecular Biology

Classics in Chemical Neuroscience: Xanomeline

Aaron M. Bender et al.

ACS CHEMICAL NEUROSCIENCE (2017)

Review Pharmacology & Pharmacy

Quantitative analysis of receptor allosterism and its implication for drug discovery

Rumin Zhang et al.

EXPERT OPINION ON DRUG DISCOVERY (2015)

Article Chemistry, Medicinal

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

Michael D. Shultz

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Medicinal

Probing Structural Requirements of Positive Allosteric Modulators of the M4 Muscarinic Receptor

Tracey Huynh et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

SAR Matrices: Automated Extraction of Information-Rich SAR Tables from Large Compound Data Sets

Anne Mai Wassermann et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Pharmacology & Pharmacy

THE ANTIPSYCHOTIC POTENTIAL OF MUSCARINIC ALLOSTERIC MODULATION

Thomas M. Bridges et al.

DRUG NEWS & PERSPECTIVES (2010)

Article Pharmacology & Pharmacy

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Cuyue Tang et al.

BIOCHEMICAL PHARMACOLOGY (2009)

Article Chemistry, Medicinal

Enhanced SAR Maps: Expanding the Data Rendering Capabilities of a Popular Medicinal Chemistry Tool

Jeremy Kolpak et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)

Article Psychiatry

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

Anantha Shekhar et al.

AMERICAN JOURNAL OF PSYCHIATRY (2008)

Article Pharmacology & Pharmacy

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

Ashley E. Brady et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Article Multidisciplinary Sciences

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

W. Y. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Pharmacology & Pharmacy

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid/plasma concentration ratio

T Ohe et al.

DRUG METABOLISM AND DISPOSITION (2003)