期刊
CHEMBIOCHEM
卷 20, 期 14, 页码 1789-1794出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201900045
关键词
aptamers; click chemistry; cyclization; G-quadruplexes; molecular recognition
资金
- Italian Association for Cancer Research (AIRC
- IG2015) [17037]
With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin-binding aptamer (TBA) analogue (cycTBA) has been prepared by exploiting a copper(I)-assisted azide-alkyne cycloaddition. The markedly increased serum resistance and exceptional thermal stability of the G-quadruplex versus TBA were associated with halved thrombin inhibition, which suggested that some flexibility in the TBA structure was necessary for protein recognition.
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