期刊
CELLULAR SIGNALLING
卷 54, 期 -, 页码 115-121出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2018.11.022
关键词
Heparan sulfate proteoglycan; Cytokines; Cellular signaling; Heparin
类别
资金
- Swedish Research Council [2015-02595]
- Swedish Cancer Foundation [CAN2015/496]
- Swedish Research Council [2015-02595] Funding Source: Swedish Research Council
Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed ubiquitously on the cell surface and in the extracellular matrix where they interact with a wide range of ligands to regulate many aspects of cellular function. The capacity of the side glycosaminoglycan chain heparan sulfate (HS) being able to interact with diverse protein ligands relies on its complex structure that is generated by a controlled biosynthesis process, involving the actions of glycosyl-transferases, sulfotransferases and the glucuronyl C5-epimerase. It is believed that activities of the modification enzymes control the HS structures that are designed to serve the biological functions in a given cell or biological status. In this review, we briefly discuss recent understandings on the roles of HSPG in cytokine stimulated cellular signaling, focusing on FGF, TGF-beta, Wnt, Hh, HGF and VEGF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据