期刊
CELLULAR IMMUNOLOGY
卷 337, 期 -, 页码 33-41出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2019.01.005
关键词
Non-alcoholic fatty liver disease; Mesenteric lymph node; T helper cells; Intestinal immune disorder; Microbiota
资金
- National Natural Science Foundation of China [81500404, 81470798]
Non-alcoholic fatty liver disease (NAFLD) is characterized by altered intestinal microbiota and intestinal immune disorder. Here we investigated the role of mesenteric lymph node (MLN) CD4(+) T lymphocytes in NAFLD. In high fat diet (HFD)-fed mice, the percentage ratios of Th1 to Th2 cells and Th17 to Treg cells were imbalanced in MLNs. Co-culture assays showed MLN CD4(+) T lymphocytes from HFD-fed mice tended to migrate to the liver and promoted hepatic inflammation. Adoptive transfer of MLN CD4(+) T lymphocytes from NAFLD mice to HFD-fed mice resulted in higher transaminase, worse hepatic inflammation and lipid accumulation. Antibiotics and probiotics were administrated to regulate intestinal microbiota, and the restoration of MLN Th1/Th2 and Th17/Treg cells in alleviated NAFLD were found. In summary, MLNs CD4(+) T subtype cells may involve in NAFLD, and the restoration of MLN CD4(+) T subtype cells ratio by regulating intestinal bacteria could be the new strategies.
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