期刊
CELL RESEARCH
卷 29, 期 5, 页码 379-390出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41422-019-0145-8
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资金
- National Natural Science Foundation of China [91640114, 31330061, 31788103, 91540203, 31600207, 31770323]
- Chinese Academy of Sciences [XDB27040201, QYZDY-SSW-SMC022]
- National Key Laboratory of Plant Molecular Genetics, the China Postdoctoral Science Foundation [2016M590386]
- State Key Laboratory of Plant Genomics, the China Postdoctoral Science Foundation [2016M590386]
- Youth Innovation Promotion Association of CAS [2018131]
Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.
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