期刊
CELL PROLIFERATION
卷 52, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/cpr.12572
关键词
central nerve system; dental stem cells; nerve repair; nervous regeneration; neural differentiation; peripheral nerve system
类别
资金
- Project of Science & Technology Bureau of Chengdu [2016-HM01-00071-SF]
- Science & Technology Department of Sichuan Province [2017SZ0094]
Nerous system diseases, both central and peripheral, bring an incredible burden onto patients and enormously reduce their quality of life. Currently, there are still no effective treatments to repair nerve lesions that do not have side effects. Stem cell-based therapies, especially those using dental stem cells, bring new hope to neural diseases. Dental stem cells, derived from the neural crest, have many characteristics that are similar to neural cells, indicating that they can be an ideal source of cells for neural regeneration and repair. This review summarizes the neural traits of all the dental cell types, including DPSCs, PDLCs, DFCs, APSCs and their potential applications in nervous system diseases. We have summed up the advantages of dental stem cells in neural repair, such as their neurotrophic and neuroprotective traits, easy harvest and low rejective reaction rate, among others. Taken together, dental stem cells are an ideal cell source for neural tissue regeneration and repair.
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