期刊
CELL CYCLE
卷 18, 期 8, 页码 784-794出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2019.1598725
关键词
Protein synthesis; protein degradation; cell cycle; single cell approaches; population-based studies
类别
资金
- Teofilo Rossi di Montelera e di Premuda Foundation
- CARIGEST SA
- Fondation Pierre Mercier
Protein expression levels depend on the balance between their synthesis and degradation rates. Even quiescent (G(0)) cells display a continuous turnover of proteins, despite protein levels remaining largely constant over time. In cycling cells, global protein levels need to be precisely doubled at each cell division in order to maintain cellular homeostasis, but we still lack a quantitative understanding of how this is achieved. Recent studies have shed light on cell cycle-dependent changes in protein synthesis and degradation rates. Here we discuss current population-based and single cell approaches used to assess protein synthesis and degradation, and review the insights they have provided into the dynamics of protein turnover in different cell cycle phases.
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