期刊
CELL AND TISSUE RESEARCH
卷 377, 期 1, 页码 21-43出版社
SPRINGER
DOI: 10.1007/s00441-019-03003-z
关键词
Chronic pain; Depression; Molecular characteristics; Behavior; Neuropathic pain
类别
资金
- Centre National de la Recherche Scientifique [UPR3212]
- University of Strasbourg
- Brain & Behavior Research Foundation [24736]
- Fondation pour la Recherche Medicale [FRM FDT201805005527]
- French National Research Agency (ANR) through the Programme d'Investissement d'Avenir [ANR-17-EURE-0022]
The increasing number of individuals with comorbidities poses an urgent need to improve the management of patients with multiple co-existing diseases. Among these comorbidities, chronic pain and mood disorders, two long-lasting disabling conditions that significantly reduce the quality of life, could be cited first. The recent development of animal models accelerated the studies focusing on the underlying mechanisms of the chronic pain and depression/anxiety comorbidity. This review provides an overview of clinical and pre-clinical studies performed over the past two decades addressing the molecular aspects of the comorbid relationship of chronic pain and depression. We thus focused on the studies that investigated the molecular characteristics of the comorbid relationship between chronic pain and mood disorders, especially major depressive disorders, from the genetic and epigenetic point of view to key neuromodulators which have been shown to play an important role in this comorbidity.
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