期刊
CELL AND TISSUE RESEARCH
卷 376, 期 1, 页码 19-24出版社
SPRINGER
DOI: 10.1007/s00441-019-02994-z
关键词
Thymus; Medulla; Lymphocyte entry; Peripheral lymphoid organs; B lymphocytes
类别
资金
- Deutsche Forschungsgemeinschaft (DFG)
The thymus is a primary lymphoid organ where T lymphocyte proliferation and selection takes place. The different subsets of lymphocytes leave the thymus as recent thymic emigrants. Peripheral dendritic cells migrate to the thymus. In addition to the homing of hematopoietic progenitor cells to the thymus, there is evidence for lymphocyte entry from peripheral lymphoid tissues mainly into the medulla. The entry sites are the venules in the medullary part near to the cortex with a higher endothelium. Furthermore, there are also B lymphocytes in the thymus. The thymus is not only a primary lymphoid organ but is well integrated in lymphocyte traffic as shown in several different species.
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